8-Stage Non-Viable Impactor Overview
PHARMACEUTICAL RESEARCH
The Eight Stage Sampler meets the guidelines of the various world pharmacopoeias (e.g., United States Pharmacopoeia Chapter 601 "USP <601>") to characterize metered-dose (MDI) and dry powder-dose inhalers (DPI), nebulizers, nasal sprays and other pulmonary drugs. Non-viable cascade impactors are important while performing research, quality assurance and equivalency testing. Introduction accessories and kits are available for these specialized applications (See USP Accessory Parts). The testing of inhalation drugs goes hand and hand with cascade impactors, the size ranges collected are considered inhalable (generally <10 μm), just as the inhalation drugs should consistently arrive within the respiratory system into their target regions, the various stages represent the cut-off sizes when deposition may occur within the lungs.
EIGHT-STAGE AMBIENT CASCADE IMPACTOR SYSTEM (P/N NS-8S-20-800) includes:
- 8 aluminum orifice stages
- 8 stainless steel collection plates
- Back-up 81mm filter holder
- Silicone o-ring gaskets
- Vacuum pump assembly
- Carrying case
SERIES NS-8S-20-800 CASCADE IMPACTOR
The Eight Stage Cascade Impactor utilizes eight jet stages for classification of aerosols from 9 micrometers and above, to 0.4 micrometers (at 28.3 lpm) this permits airborne particulate to impact upon stainless steel impaction surfaces or your choice of filter media, depending on type of chemical analysis. A final filter collects all particles smaller than 0.4 μm. Preseparators and special jet stages and optional inlets allow the cascade impactor to operate at higher flow rates, particularly 60 liters per minute (lpm) and 90 liters per minute (lpm), permitting collection of sub-micron particulate.
CUT POINTS FOR THE EIGHT STAGE CASCADE IMPACTOR
The jet on every stage of the cascade impactor is individually inspected by an advanced digital video optical comparator. The IVIS (Impactor Visual Inspection System) allows for documentation of the jet critical diameters in a graph type report. The permanent record verifies the placement and diameters of each jet, verifying the instrument's performance and can be used as a future reference to recertify the cascade impactor. USP <601> for Pharmaceutical applications requires this stage mensuration procedure first, as well as periodic inspection to insure jet opening quality is maintained and optimum performance occurs.
Standard Flow Configuration
60 lpm Flow Rate Configuration Kit Installed
90 lpm Flow Rate Configuration Kit Installed
